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Abstract #3972

Optimization of Post Contrast T1 Mapping Time for Diagnostic Assessment of Myocardial Amyloid

Mitchell Anthony Cooper 1 , Thanh D. Nguyen 2 , Jonathan Weinsaft 3 , Matthew Maurer 4 , Suzanne Lentzsch 4 , Heather Landau 5 , Jiwon Kim 5 , Sattar Gojraty 3 , Silvina Dutruel 2 , Martin Prince 2 , and Yi Wang 2

1 Biomedical Engineering, Cornell University, Ithaca, New York, United States, 2 Radiology, Weill Cornell Medical College, New York, NY, United States, 3 Cardiology, Weill Cornell Medical College, New York, New York, United States, 4 Columbia University, New York, New York, United States, 5 Memorial Sloan Kettering Cancer Center, New York, New York, United States

Cardiac amyloidosis is a serious condition in which insoluble proteins accumulate in the extracellular space of the myocardium, resulting in impaired cardiac function. The current gold standard for the evaluation of cardiac involvement is endomyocardial biopsy, an invasive procedure not well suited for screening purposes or serial assessment. Myocardial T1 mapping after the administration of a Gadolinium (Gd) contrast agent, which acts as a diffusible tracer, has emerged as a viable noninvasive tool to detect amyloid infiltration and to quantify changes in the extravascular extracellular volume (ECV) in cardiac amyloidosis (1-3).The purpose of this study was to identify the optimal T1 mapping time by performing numerical simulation of a tracer kinetic model as well as by measuring myocardial T1 at various time points in healthy and amyloid positive patients.

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