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Abstract #3829

Image-guided Pro-angiogenic Therapy in Diabetic Stroke Mouse Model with a Multi-modal Nanoprobe

Ying-Ying Bai 1 and Shenghong Ju 1

1 Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospita, Nanjing, Jiangsu, China

This study demonstrated that the neovasculature targeted nanoprobe can specifically evaluate angiogenesis in ischemic stroke. Molecular imaging demonstrated impaired angiogenesis in the diabetic mice and revealed the pro-angiogenic effects of EPC, the precursor cell of endothelial cell. While current clinical techniques for monitoring therapeutic efficacy, such as blood flow measurements, are capable of detecting large caliber vessels that form at the late stages of revascularization, molecular imaging with targeted contrast agents can map the early signatures of angiogenesis. In clinical practice, earlier detection of therapeutic response could be invaluable for guiding therapies, including determining effective drug doses and evaluating new treatment strategies.

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