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Abstract #3830

Interleaved Magnetic Steering and MR imaging of USPIO Particles in One Dimension: Early Results

Hsin-Jung Yang 1 , Ke Cheng 1 , Ryan middleton 1 , Ivan Cokic 1 , Avinash Kali 1 , Louis Bouchard 2 , Eduardo Marban 1 , and Rohan Dharmakumar 1

1 Cedars Sinai Medical Center, Los Angeles, California, United States, 2 UCLA, Los Angeles, California, United States

Retention of cells within regions of interest following their delivery is a known obstacle in the field of regenerative medicine. Recent studies have demonstrated that magnetic field gradient of bar magnets can be used to couple with the dipole moment of the cells labeled with iron oxide can be used to enhance retention and therapeutic regeneration. In this work, we investigated whether a Maxwell coil, which can be positioned within the MR scanner, would be able to deliver sufficient one-dimensional force on USPIO particles and the effect of this resultant force can be captured on the basis of T2* MRI.

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