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Abstract #3828

Sub-5 nm Ultrafine Iron Oxide Nanoparticles for Tumor Imaging: Novel Contrast and Improved Tumor Uptake

Liya Wang 1,2 , Jing Huang 1,2 , Xiaodong Zhong 3 , Hui Wu 1,2 , Lily Yang 4 , and Hui Mao 1,2

1 Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia, United States, 2 Center for System Imaging, Emory University School of Medicine, Atlanta, Georgia, United States, 3 MR R&D Collaborations, Siemens Healthcare, Atlanta, Georgia, United States, 4 Surgery, Emory University School of Medicine, Atlanta, Georgia, United States

This study demonstrated the application of novel sub-5 nm ultra-fine iron oxide (UFIO) nanoparticles in imaging of xenograft tumors. The results showed higher tumor uptake of UFIO nanoparticles comparing to iron oxide nanoparticles (IONPs) with larger sizes, suggesting that the penetration and accumulation of IONPs in tumor tissue is size dependent. The transition from T1 contrast in the tumor vasculature in the early phase of post-injection to the T2 contrast at later phase, i.e., 24 hours after the injection of UFIO nanoparticles may provide a novel capability for following a dynamic process of delivery of UFIO probes to the tumor.

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