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Abstract #3823

Assessment of the size window of tumor vascular permeability using dextran-based CEST MRI

Yuguo Li 1,2 , Kannie Chan 1,2 , Yuan Qiao 3 , Jiadi Xu 2 , Jeff Bulte 1 , Bert Vogelstein 3 , Michael McMahon 1,2 , Shibin Zhou 3 , Peter van Zijl 1,2 , and Guanshu Liu 1,2

1 Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2 FM Kirby center, Kennedy Krieger Institute, Baltimore, MD, United States, 3 Ludwig Center, Howard Hughes Medical Institute and Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Assessing tumor vascular permeability has important applications in clinical diagnosis and for the development of personalized nanoparticulate therapeutics. Here, we explored dextran as a potential Chemical Exchange Saturation Transfer (CEST) imaging agent by utilizing the CEST contrast originating from OH protons on the glucose units. Contrast was studied for particle sizes ranging from 4-60 nm. Dextrans of different molecular weights could be readily detected using CEST MRI. The differential permeability of an experimental tumor to dextrans sized at 4 and 14 nm was detected and renal clearance of the agents was also monitored.

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