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Abstract #3824

Generating Positive Contrast from Magnetic Nanoparticles Using a SubShortTE Method with Conventional Spin Echo Sequences

Xiaodong Zhong 1 , Liya Wang 2,3 , Jing Huang 2,3 , and Hui Mao 2,3

1 MR R&D Collaborations, Siemens Healthcare, Atlanta, GA, United States, 2 Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States, 3 Center for Systems Imaging, Emory University School of Medicine, Atlanta, GA, United States

This study demonstrates a new method of SubShortTE, i.e. subtraction of a later echo signal from an earlier echo signal, with widely available SE/TSE sequences for generating positive contrast from magnetic nanoparticle contrast agents. This approach was evaluated with theoretical simulation and phantom imaging using iron oxide nanoparticles (IONP) with different sizes and concentrations. The results demonstrated that positive contrast could be obtained in IONP phantoms using this approach. SubShortTE could potentially provide a robust alternative method to the other positive contrast methods for molecular imaging and cell tracking applications without the need of any special sequences.

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