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Abstract #3822

In-Vivo Temperature Measurement using ParaCEST MRI Contrast Agents at 9.4T

Nevin McVicar 1,2 , Alex X Li 2 , Mojmir Suchy 3 , Robert H Hudson 3 , and Robert Bartha 1,2

1 Medical Biophysics, University of Western Ontario, London, Ontario, Canada, 2 Centre for Functional and Metabolic Mapping, Robarts Research Institute, London, Ontario, Canada, 3 Chemistry, University of Western Ontario, London, Ontario, Canada

Tissue temperature is measured in-vivo in mouse leg muscle following intramuscular injection of a paraCEST contrast agent using magnetic resonance imaging (MRI). Tissue MRI properties including relaxation time constants, diffusion coefficients and magnetization transfer effects were measured before and after paraCEST injection. Significant changes in tissue MR properties were observed between pre- and post-injection data. Only apparent diffusion coefficient correlated with measured tissue temperature. The paraCEST tissue temperature measurements were in agreement with true tissue temperature. Therefore, in-vivo tissue temperature measurements made using paraCEST contrast agents following direct injection are accurate despite changes in tissue relaxation properties.

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