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Abstract #3821

Anti-angiogenic therapy follow-up in mice brain glioma model with P04000, a new molecular imaging avb3-nanoemulsion of iron oxide.

VIOLAS Xavier 1 , ROBERT Philippe 2 , NAIN DIT DUCRET Martine 2 , ROBIC Caroline 2 , BALLET Sebastien 2 , and COROT Claire 2

1 Guerbet, Aulnay sous bois, France, 2 Guerbet, France

A new iron oxide nanoparticle based USPIO (P04000) is evaluated in terms of specificity and capacity to monitor antiangiogenic treatment in a brain tumor model in mice. The high affinity rgd vectored contrast agent who targets avb3 allows, with a basic Multi Gradient Echo sequence, to specifically enhance the tumor 2 hours post injection. The uptake of this agent is reduced to zero in the bevacizumab treated group before the tumor regression. This MR contrast agent is able to early demonstrate the effect of anti-angiogenic therapy with feasible MRI sequence and data post processing in humans.

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