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Abstract #3817

Ultrafast 129Xe Hyper-CEST

Cline Boutin 1 , Estelle Lonce 2 , Thierry Brotin 3 , Alexej Jerschow 4 , and Patrick Berthault 2

1 IRAMIS, SIS2M, UMR CEA/CNRS 3299, CEA Saclay, Gif-sur-Yvette, Gif sur Yvette, France, 2 IRAMIS, SIS2M, UMR CEA/CNRS 3299, CEA Saclay, Gif sur Yvette, France, 3 Laboratoire de Chimie, CNRS, Ecole Normale Suprieure de Lyon, Lyon, France, 4 Chemistry Department, New York University, New York, NY, United States

129Xe biosensors have been demonstrated to provide sensitive probes of biological events. Very sensitive detection thresholds can be reached with the HyperCEST approach. We report herein the use of ultra-fast Z-spectroscopy as a powerful means to detect low concentrations of 129Xe NMR-based sensors in a single shot. This experiment enables a multiplexed detection of several sensors, as well as the extraction of the exchange buildup rate constant in a single-shot fashion. The ultrafast method makes it possible to provide ultra-fast and high-throughput sampling of biomarker mixtures.

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