Abstract #3817
Ultrafast 129Xe Hyper-CEST
Cline Boutin 1 , Estelle Lonce 2 , Thierry Brotin 3 , Alexej Jerschow 4 , and Patrick Berthault 2
1
IRAMIS, SIS2M, UMR CEA/CNRS 3299, CEA
Saclay, Gif-sur-Yvette, Gif sur Yvette, France,
2
IRAMIS,
SIS2M, UMR CEA/CNRS 3299, CEA Saclay, Gif sur Yvette,
France,
3
Laboratoire
de Chimie, CNRS, Ecole Normale Suprieure de Lyon, Lyon,
France,
4
Chemistry
Department, New York University, New York, NY, United
States
129Xe biosensors have been demonstrated to provide
sensitive probes of biological events. Very sensitive
detection thresholds can be reached with the HyperCEST
approach. We report herein the use of ultra-fast
Z-spectroscopy as a powerful means to detect low
concentrations of 129Xe NMR-based sensors in a single
shot. This experiment enables a multiplexed detection of
several sensors, as well as the extraction of the
exchange buildup rate constant in a single-shot fashion.
The ultrafast method makes it possible to provide
ultra-fast and high-throughput sampling of biomarker
mixtures.
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