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Abstract #3818

Targeting radiation-induced neuroinflammation using ICAM-MPIO

Benedicte Descamps 1 , Sara Neyt 2 , Caroline Dumolyn 2 , Elke Decrock 3 , Julie Bolcaen 4,5 , Ingeborg Goethals 4,5 , Tom Boterberg 6,7 , Filip De Vos 2 , Christian Vanhove 1,8 , and Karel Deblaere 4,9

1 Infinity - Medisip - iMinds, Ghent University, Ghent, Belgium, 2 Radiopharmacy, Ghent University, Ghent, Belgium, 3 Basic Medical Sciences, Ghent University, Ghent, Belgium, 4 Radiology and Nuclear Medicine, Ghent University, Ghent, Belgium, 5 Nuclear Medicine, Ghent University Hospital, Ghent, Belgium, 6 Radiotherapy and Experimental Cancer Research, Ghent University, Ghent, Belgium, 7 Radiotherapy, Ghent University Hospital, Ghent, Belgium, 8 GROUP-ID, Ghent University, Ghent, Belgium, 9 Radiology and Medical Imaging, Ghent University Hospital, Ghent, Belgium

Iron oxide-based contrast agents can be labeled with antibodies to image selectively targeted molecular processes using MRI. Intercellular adhesion molecule (ICAM1) plays a key role in the early inflammatory cascade following brain irradiation. This protein mostly expresses on the luminal surface of the endothelium of brain venules and capillaries and promotes the recruitment and migration of leukocytes. We show that micron-sized particles of iron oxide (MPIO) labeled with anti-ICAM1 antibodies are a useful tool to selectively image the local upregulation of endothelial ICAM1 expression in an animal model of early radiation injury using T2*w MRI.

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