Abstract #3818
Targeting radiation-induced neuroinflammation using ICAM-MPIO
Benedicte Descamps 1 , Sara Neyt 2 , Caroline Dumolyn 2 , Elke Decrock 3 , Julie Bolcaen 4,5 , Ingeborg Goethals 4,5 , Tom Boterberg 6,7 , Filip De Vos 2 , Christian Vanhove 1,8 , and Karel Deblaere 4,9
1
Infinity - Medisip - iMinds, Ghent
University, Ghent, Belgium,
2
Radiopharmacy,
Ghent University, Ghent, Belgium,
3
Basic
Medical Sciences, Ghent University, Ghent, Belgium,
4
Radiology
and Nuclear Medicine, Ghent University, Ghent, Belgium,
5
Nuclear
Medicine, Ghent University Hospital, Ghent, Belgium,
6
Radiotherapy
and Experimental Cancer Research, Ghent University,
Ghent, Belgium,
7
Radiotherapy,
Ghent University Hospital, Ghent, Belgium,
8
GROUP-ID,
Ghent University, Ghent, Belgium,
9
Radiology
and Medical Imaging, Ghent University Hospital, Ghent,
Belgium
Iron oxide-based contrast agents can be labeled with
antibodies to image selectively targeted molecular
processes using MRI. Intercellular adhesion molecule
(ICAM1) plays a key role in the early inflammatory
cascade following brain irradiation. This protein mostly
expresses on the luminal surface of the endothelium of
brain venules and capillaries and promotes the
recruitment and migration of leukocytes. We show that
micron-sized particles of iron oxide (MPIO) labeled with
anti-ICAM1 antibodies are a useful tool to selectively
image the local upregulation of endothelial ICAM1
expression in an animal model of early radiation injury
using T2*w MRI.
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