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Abstract #3816

Safety and Efficacy Evaluation Of A Novel Graphene-Based Nanoparticles As An MRI Blood Pool Agent

Shruti Kanakia 1 , Dung Minh Hoang 2 , Jimmy Toussaint 1 , Sayan Mullick Chowdhury 1 , Stephen Lee 1 , Kenneth R Shroyer 3 , William Moore 4 , Balaji Sitharaman 1 , and Youssef Zaim Wadghiri 2

1 Biomedical Engineering, Stony Brook University, Stony Brook, NY, United States, 2 Radiology, Bernard & Irene Schwartz Center for Biomedical Imaging, NYU School of Medicine, New York, NY, United States, 3 Pathology, Stony Brook University, Stony Brook, NY, United States, 4 Radiology, Stony Brook University, Stony Brook, NY, United States

We report pre-clinical in vivo small animal safety and efficacy studies of a novel graphene-based blood pool MRI CA. The formulation called Mn-GNP-Dex (disk-shaped, thickness=3-4 nm, diameter ~100 nm) consists of graphene nanoparticles intercalated with manganese Mn2+ ions, are water-solubilized with dextran and have r1 relaxivity 92 mM-1S-1. The results show that the Mn-GNP-Dex formulation is safe, does not show any toxic effect in the animals with renal insufficiency, remains in blood for up to 2 hours and is more efficacious than clinical blood pool CA Ablavar. Hence, Mn-GNP-Dex has great potential for development as high performance T1 blood pool MRI CA.

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