Abstract #3816
Safety and Efficacy Evaluation Of A Novel Graphene-Based Nanoparticles As An MRI Blood Pool Agent
Shruti Kanakia 1 , Dung Minh Hoang 2 , Jimmy Toussaint 1 , Sayan Mullick Chowdhury 1 , Stephen Lee 1 , Kenneth R Shroyer 3 , William Moore 4 , Balaji Sitharaman 1 , and Youssef Zaim Wadghiri 2
1
Biomedical Engineering, Stony Brook
University, Stony Brook, NY, United States,
2
Radiology,
Bernard & Irene Schwartz Center for Biomedical Imaging,
NYU School of Medicine, New York, NY, United States,
3
Pathology,
Stony Brook University, Stony Brook, NY, United States,
4
Radiology,
Stony Brook University, Stony Brook, NY, United States
We report pre-clinical in vivo small animal safety and
efficacy studies of a novel graphene-based blood pool
MRI CA. The formulation called Mn-GNP-Dex (disk-shaped,
thickness=3-4 nm, diameter ~100 nm) consists of graphene
nanoparticles intercalated with manganese Mn2+ ions, are
water-solubilized with dextran and have r1 relaxivity 92
mM-1S-1. The results show that the Mn-GNP-Dex
formulation is safe, does not show any toxic effect in
the animals with renal insufficiency, remains in blood
for up to 2 hours and is more efficacious than clinical
blood pool CA Ablavar. Hence, Mn-GNP-Dex has great
potential for development as high performance T1 blood
pool MRI CA.
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