Abstract #3815
Noninvasive Imaging of Angiogenesis with a 3 Integrin-targeted Multi-modality Nanoprobe in Myocardial Infarction Model
Di Chang 1
1
Department of Radiology, Jiangsu Key
Laboratory of Molecular and Functional Imaging, Zhongda
Hospital, Southeast University, Nanjing, Jiangsu, China
Angiogenesis is defined as blood vessel formation from a
pre-existing vasculature, the formation of which can
promote the recovery of cardiac blood flow after
myocardial infarction. Proliferating endothelial cells
highly express a number of integrins associated with
angiogenesis, of which ͦ3 has been shown to be
particularly important. Cyclic peptide containing an
arginine-glycine-aspartic acid (cyclic RGD) sequence has
a high affinity to ͦ3 integrin. The objective of
this study was to design and develop a novel cyclic RGD
probe based multi-modality imaging for evaluation of
angiogenesis in myocardial infarction model.
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