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Abstract #3797

Assessment of acute inflammatory liver injury in a rat CCl4 model using metabolic imaging of hyperpolarized [1-13C]pyruvate

Sonal Josan 1,2 , Kelvin Billingsley 1,3 , Juan Orduna 2 , Jae Mo Park 1 , Richard Luong 4 , Srinevas Reddy 5 , Ralph Hurd 6 , Adolf Pfefferbaum 2,7 , Daniel Spielman 1 , and Dirk Mayer 1,8

1 Radiology, Stanford University, Stanford, CA, United States, 2 SRI International, Menlo Park, CA, United States, 3 Chemistry and Biochemistry, San Francisco State University, San Francisco, CA, United States, 4 Comparative Medicine, Stanford University, Stanford, CA, United States, 5 Surgery, University of Maryland, Baltimore, MD, United States, 6 GE Healthcare, CA, United States, 7 Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, United States, 8 Diagnostic Radiology and Nuclear Medicine, University of Maryland, Baltimore, MD, United States

Numerous studies using hyperpolarized pyruvate (Pyr) have been applied to investigate cancer and heart disease, but very few reports have been published on applications in diseased liver other than cancer. As several liver pathologies are associated with elevated alanine transaminase (ALT) activity, the aim of this work was to investigate the use of dynamic metabolic imaging of hyperpolarized [1-13C]Pyr for the assessment of liver damage induced by administration of carbon tetrachloride (CCl4).

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