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Abstract #3796

Robust Single-Shot Hyperpolarized 13 C Spectroscopic Imaging Utilizing Incoherent k-t spiral Sampling and Low-Rank Matrix Completion

Jeremy W Gordon 1 , Sean B Fain 1,2 , David J Niles 1 , and Kevin M Johnson 1,2

1 Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, 2 Radiology, University of Wisconsin-Madison, Madison, WI, United States

Joint spatial-spectral reconstruction enables highly accelerated 13 C spectroscopic imaging but requires high performance gradients to optimally sample k-t space. However, temporal correlations between adjacent timeframes can be exploited by permuting or shifting the TE to reduce gradient requirements while still sampling k-t space sufficiently. Simulations and in-vivo results indicate that by permuting the k-t trajectory via pseudorandom TEs and incorporating low-rank regularization, temporal correlations across timeframes can be incorporated to improve the conditioning of the encoding matrix and reduce noise in low signal metabolite images. The proposed framework reduces gradient requirements and may enable k-t spiral sampling on clinical platforms.

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