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Abstract #3798

Gradient-Enhanced Effectively Decoupled INEPT (GREEDI)

Daniel Spielman 1 , Keshav Datta 2 , Sonal Josan 3 , Stephen Lynch 4 , and Ralph Hurd 5

1 Radiology, Stanford University, Stanord, CA, United States, 2 Electrical Engineering, Stanford University, CA, United States, 3 Radiology, Stanford University, CA, United States, 4 Chemistry, Stanford University, CA, United States, 5 GE Healthcare, CA, United States

Polarization transfer methods provide improved detection of 13C nuclei directly bonded to protons. However, efficient in vivo measurements are difficult due to SAR-intensive decoupling requirements. Here we present a modification to the conventional INEPT sequence that eliminates splitting due to short-range 13C-1H J-coupling, while providing a √2 SNR gain, without the need for proton decoupling. The targeted application is enhanced imaging and spectroscopy of [2-13C]Lac and [2-13C]Ala (metabolic products generated by hyperpolarized [2-13C]Pyr), however the approach may also be applicable to detecting C2, C3, and C4 glutamate and glutamine resonances following infusion of thermally polarized 13C-substrates.

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