Abstract #3798
Gradient-Enhanced Effectively Decoupled INEPT (GREEDI)
Daniel Spielman 1 , Keshav Datta 2 , Sonal Josan 3 , Stephen Lynch 4 , and Ralph Hurd 5
1
Radiology, Stanford University, Stanord, CA,
United States,
2
Electrical
Engineering, Stanford University, CA, United States,
3
Radiology,
Stanford University, CA, United States,
4
Chemistry,
Stanford University, CA, United States,
5
GE
Healthcare, CA, United States
Polarization transfer methods provide improved detection
of 13C nuclei directly bonded to protons. However,
efficient in vivo measurements are difficult due to
SAR-intensive decoupling requirements. Here we present a
modification to the conventional INEPT sequence that
eliminates splitting due to short-range 13C-1H
J-coupling, while providing a √2 SNR gain, without the
need for proton decoupling. The targeted application is
enhanced imaging and spectroscopy of [2-13C]Lac and
[2-13C]Ala (metabolic products generated by
hyperpolarized [2-13C]Pyr), however the approach may
also be applicable to detecting C2, C3, and C4 glutamate
and glutamine resonances following infusion of thermally
polarized 13C-substrates.
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