Abstract #3783
Reduced concentrations of GABA and NAA in the thalamus of patients with juvenile myoclonus epilepsy
Ulrich Pilatus 1 , Christian Lckerath 1 , Stefanie Pellikan 1 , Dmitri Vronski 1 , Susanne Knake 2 , Matthias Kieslich 3 , and Elke Hattingen 1
1
Institute of Neuroradiology,
Goethe-University Frankfurt, Frankfurt, Germany,
2
Centrum
of Epilepsy Hessen, Philipps-University Marburg,
Marburg, Germany,
3
Department
of Pediatric Neurology, Goethe-University Frankfurt,
Frankfurt, Germany
In juvenile myoclonic epilepsy (JME) dysfunction of
thalamocortical circuits is considered to trigger
myoclonic seizures and frontal lobe dysfunction is a
common pathology. Here we present data on metabolite
concentrations in brain structures relevant for JME
(thalamus, frontal lobe, motor cortex) focusing on
changes of GABA, glutamate, glutamine and NAA. In
addition to short-TE MR spectroscopy a specific MR
spectroscopic GABA editing sequences was employed. The
study was designed to obtain information of drug
effects, hemispheric and tissue differences, too.
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