Meeting Banner
Abstract #3783

Reduced concentrations of GABA and NAA in the thalamus of patients with juvenile myoclonus epilepsy

Ulrich Pilatus 1 , Christian Lckerath 1 , Stefanie Pellikan 1 , Dmitri Vronski 1 , Susanne Knake 2 , Matthias Kieslich 3 , and Elke Hattingen 1

1 Institute of Neuroradiology, Goethe-University Frankfurt, Frankfurt, Germany, 2 Centrum of Epilepsy Hessen, Philipps-University Marburg, Marburg, Germany, 3 Department of Pediatric Neurology, Goethe-University Frankfurt, Frankfurt, Germany

In juvenile myoclonic epilepsy (JME) dysfunction of thalamocortical circuits is considered to trigger myoclonic seizures and frontal lobe dysfunction is a common pathology. Here we present data on metabolite concentrations in brain structures relevant for JME (thalamus, frontal lobe, motor cortex) focusing on changes of GABA, glutamate, glutamine and NAA. In addition to short-TE MR spectroscopy a specific MR spectroscopic GABA editing sequences was employed. The study was designed to obtain information of drug effects, hemispheric and tissue differences, too.

This abstract and the presentation materials are available to members only; a login is required.

Join Here