Abstract #3784
Metabolite changes of insular cortices in patients with obstructive sleep apnea
Rajesh Kumar 1 , Santosh K Yadav 1 , Paul M Macey 2 , Mary A Woo 2 , Frisca L Yan-Go 3 , and Ronald M Harper 4
1
Anesthesiology, University of California at
Los Angeles, Los Angeles, CA, United States,
2
UCLA
School of Nursing, University of California at Los
Angeles, Los Angeles, CA, United States,
3
Neurology,
University of California at Los Angeles, Los Angeles,
CA, United States,
4
Neurobiology,
University of California at Los Angeles, Los Angeles,
CA, United States
Obstructive sleep apnea (OSA) subjects show both
structural injury and functional deficits in multiple
brain sites, and these deficits are especially prominent
in the anterior insular cortices that assist regulation
of autonomic and neuropsychologic functions. We examined
anterior insular metabolites using PMRS to determine the
nature of tissue changes in OSA, and observed
bilaterally reduced NAA, and increased MI on the left
side, indicating neuronal damage/loss of function, and
glial activation, respectively. The presence of abnormal
metabolites in OSA may result from intermittent hypoxia,
impaired perfusion, or deficient micronutrient support
accompanying the condition.
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