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Abstract #3782

Anterior Cingulate Glutamate Concentrations as a Window to Study Impact of Inflammation on Behavior

Xiangchuan Chen 1 , Xiaoping Hu 1 , Andrew H. Miller 2,3 , and Ebrahim Haroon 2,3

1 Biomedical Imaging Technology Center, Emory University, Atlanta, GA, United States, 2 School of Medicine, Emory University, Atlanta, GA, United States, 3 Winship Cancer Institute, Atlanta, GA, United States

Increased neural and glial activity in several brain regions including dorsal anterior cingulate cortical (dACC) regions has been reported to occur in response to inflammatory activation by infections, cancer and chronic psychological stress. We designed a study to test the hypothesis that depressed patients with CRP > 3mg / L (high inflammation) will show an increase in the dACC glutamate and inositol levels indicating high levels of neuronal and glial activation and further that the neural metabolite changes will be directly and positively correlated with inflammatory biomarkers seen in plasma.

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