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Abstract #3781

Subcortical Glutamate Increase Suggestive of Glial Toxicity in Depressed patients with High Inflammation

Li Wei 1,2 , xiaoping Hu 1,2 , Andrew H Miller 2,3 , and Ebrahim Haroon 2,3

1 Biomedical Imaging Technology Center, Emory University, Atlanta, GA, United States, 2 School of Medicine, Emory University, Atlanta, GA, United States, 3 Winship Cancer Institute, Atlanta, GA, United States

Chronic immune activation forms the basis of many medical and behavioral disorders. The mechanism of the association between immune changes and behavior disorder is not clear. We hypothesize that the link might reside in the metabolism of glutamate, an excitatory amino acide neurotransmitter. Interestingly unbridled increase in glutamate concentration might result in neurodegenwerative and behavioral changes. We studied 9 depressed patients with high inflammation and compared them to 15 patients who had depression with low inflammation. We measured glutamate concentrations in the bilateral basal ganglia using chemical shift imaging (MRS). Depressed patients with high inflammation had significantly increased concentrtion of glutamate/creatine, choline/creatine and inositol/creatine that supporting our intial hypothesis.

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