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Abstract #3780

Glutamatergic changes detected upon functional activation with a Stroop Task in healthy controls and in subjects with Schizophrenia

Reggie Taylor 1,2 , Betsy Schaefer 3 , Richard Neufeld 3 , Peter Williamson 1,3 , and Jean Theberge 1,2

1 Medical Biophysics, Western University, London, ON, Canada, 2 Lawson Health Research Institute, London, ON, Canada, 3 Psychiatry, Western University, London, ON, Canada

The glutamatergic response to functional activation in the anterior cingulate cortex (ACC) was examined in 14 healthy controls (HC), 14 subjects with schizophrenia (SZ), and 10 subjects with mood disorder. The ACC was activated using a Stroop task, which is known to activate the area, and the glutamatergic response was monitored using 1H-MRS. Significant (p<0.05) increases were observed in both HC and SZ groups, but not the mood group. This ongoing study is the first to report on the ability of patients with SZ to dynamically regulate their levels of ACC Glu.

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