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Abstract #3779

2D L-COSY at 7T Detects Glutamate, Glutamine, Glutathione and GABA in Patients with Schizophrenia

Gaurav Verma 1 , David Roalf 2 , Ruben Gur 2 , Raquel Gur 2 , and Harish Poptani 1

1 Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2 Psychiatry, University of Pennsylvania, Philadelphia, PA, United States

Irregularities in cortical glutamate, glutamine, glutathione and gamma-aminobutyric acid (GABA) have been correlated with symptoms of schizophrenia, yet these spectral overlap with nearby resonances makes these metabolites difficult to resolve. Two-dimensional (2D) localized correlated spectroscopy (L-COSY) at 7T facilitates the unambiguous detection of these metabolites. Twelve subjects (six patients, six controls) were scanned with L-COSY at 7T. Glutamate, glutamine, glutathione and GABA were reliably detected using L-COSY with coefficients of variation of 20% or below and Glutathione was found to be significantly higher in the patient group. L-COSY could have potential application in monitoring treatment response in schizophrenia patients.

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