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Abstract #3776

Correlation of GABA Levels and Motor Performance in Parkinsons disease

Shalmali Dharmadhikari 1,2 , Swaantje Casjens 3 , Benjamin Glaubitz 4 , Martin Lehnert 3 , Clara Quetscher 3 , Anne Lotz 3 , Thomas Brning 3 , Tobias Schmidt-Wilcke 4 , Christian Beste 5 , Beate Pesch 3 , Dirk Woitalla 6 , and Ulrike Dydak 1,2

1 School of Health Sciences, Purdue University, W Lafayette, Indiana, United States, 2 Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, United States, 3 Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-Universitt Bochum (IPA), Bochum, Germany, 4 Department of Neurology, BG-Klinikum Bergmannsheil, Ruhr-University, Bochum, Germany, 5 Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, University of Dresden, Germany, 6 Neurological Clinic, St. Josef-Hospital, Ruhr-Universitt Bochum, Bochum, Germany

Parkinsons disease (PD) is caused by loss of dopamine in the basal ganglia which in turn affects the gamma-aminobutyric acid (GABA) and glutamate metabolism in the motor pathways. This study investigated the association of GABA and glutamate levels measured by MRS in the basal ganglia with motor scores obtained in PD patients in order to understand the implications of such disruptions on motor performance. Higher thalamic GABA levels were found to be associated with increasing tremor and worse motor performance.

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