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Abstract #3777

Increased Thalamic GABA and Decreased Glutamate-Glutamine in Chronic Manganese-exposed Metal Workers and Manganism Patients

Zaiyang Long 1,2 , Yue-Ming Jiang 3 , Xiang-Rong Li 4 , Jun Xu 2 , Chien-Lin Yeh 1,2 , Li-Ling Long 4 , Wei Zheng 1 , James B Murdoch 5 , and Ulrike Dydak 1,2

1 School of Health Sciences, Purdue University, West Lafayette, IN, United States, 2 Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States, 3 Department of Health Toxicology, Guangxi Medical University, Nanning, Guangxi, China, 4 Department of Radiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China, 5 Toshiba Medical Research Institute USA, Mayfield Village, OH, United States

Metal workers chronically exposed to manganese (Mn) may suffer from its neurotoxic effects, which may lead to Parkinson-type symptoms. In a search for early signs of Mn neurotoxicity, we investigated Mn accumulation in the brain as well as changes in thalamic γ-aminobutyric acid (GABA) and cortical glutamate levels in 39 metal workers, 37 controls and 7 manganism patients. Significantly decreased T1 values indicate Mn accumulation in the workers brains. Significantly elevated thalamic GABA levels in all, and decreased glutamate levels in several of the groups may help further elucidate the underlying mechanisms and serve as early biomarkers of Mn neurotoxicity.

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