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Abstract #3775

Elevated glutamate levels in the visual cortex of patients with Migraine detected at 7 Tesla

Jannie P Wijnen 1,2 , Ronald Zielman 3 , Andrew Webb 2 , Gisela M Terwindt 3 , Michel Ferrari 3 , Hermien E Kan 2 , and Mark C Kruit 2

1 Radiology, University Medical Centre Utrecht, Utrecht, Utrecht, Netherlands, 2 Radiology, Leiden University Medical Centre, Leiden, Netherlands, 3 Neurology, Leiden University Medical Centre, Leiden, Netherlands

In this study we assessed the interictal (between attacks) glutamate levels of migraine patients and compared the levels to age and gender matched healthy controls. Ultra high field Magnetic Resonance Spectroscopy (7 Tesla) of the visual cortex was performed in 20 patients and 20 controls. Linear regression of between subject effects was performed on the glutamate concentration with the fraction of gray matter (GM) in the voxel as covariate. This analysis revealed elevated interictal glutamate levels in patients with migraine. At ultra high field, glutamate can be robustly detected, which opens opportunities to study the role of glutamate in migraine in more detail.

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