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Abstract #3774

Measurement of Lactate Concentrations in the Breast Mammary Tumors Using Selective Multiple Quantum Coherence Editing Sequence at 4.7T

Sunitha Thakur 1 , Sanjay Annarao 2 , Louisa Bokacheva 3 , and Junh Hun Oh 4

1 Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, United States, 2 Memorial Sloan-Kettering Cancer Center, New York, NY, United States, 3 Medical Physics, Memorial Sloan-Kettering Cancer Center, NY, United States, 4 Memorial Sloan-Kettering Cancer Center, NY, United States

The purpose of this study is to measure lactate concentrations, [Lac] in breast mammary tumors (MCF7, BT474, MDA231, and MDA435) with contrasting growth rates, tumor aggressiveness, and metastatic risk. In this work, we implemented the SS-SelMQC using higher order binomial pulses (SS1-SelMQC) for lactate detection as well as T1- and T2- versions of SS1-SelMQC. The [Lac] in tumors were measured at different tumor volumes. In all four tumor types, the [Lac] was found to be higher at tumor volume (100-200 mm 3 ), and as tumor volume increases, [Lac] tend to decrease. No significant differences in [Lac] were found among different models.

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