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Abstract #3773

Cortical Proton MR Spectroscopic Imaging Abnormalities in a Macaque Model of NeuroAIDS

William E. Wu 1 , Assaf Tal 1 , James S. Babb 1 , Eva-Maria Ratai 2 , R. Gilberto Gonzalez 2 , and Oded Gonen 1

1 Radiology, New York University School of Medicine, New York, New York, United States, 2 Neuroradiology, Massachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts, United States

As ~40% of HIV-infected persons experience neurocognitive decline, we test whether proton MR spectroscopic imaging can detect early metabolic abnormalities in the cerebral cortex of an accelerated (CD8+ T-lymphocyte depleted) simian immunodeficiency virus-infected macaque model of neuroAIDS. Mean pre infection concentrations of glial markers, myo-inositol, creatine and choline: 5.80.9, 7.20.4 and 0.90.1mM increased 28% (p=0.06), 15% and 10% (both ps0.05) four to six weeks post-infection, while neuronal marker, N-acetylaspartate, remained unchanged (7.00.6 to 7.30.8mM). Taken together with previous studies, these findings suggest treatment regimens aimed at reducing cortical gliosis may reduce the risk of neurodegeneration and its associated neurocognitive impairments.

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