Abstract #3748
Optimizing the location of the 13 C inversion pulse in a modified INEPT sequence: Illustration with 13 C 3 glutamate
Atiyah Yahya 1,2 and Peter S. Allen 3
1
Department of Medical Physics, Cross Cancer
Institute, Edmonton, Alberta, Canada,
2
Department
of Oncology, University of Alberta, Edmonton, Alberta,
Canada,
3
Department
of Biomedical Engineering, University of Alberta,
Edmonton, Alberta, Canada
Two versions of a modified
13
C
INEPT sequence were considered at 3 T. The difference
between the two versions is the location of the
13
C
inversion pulse, namely, 1/4J
CH
after
the first proton pulse or 1/4J
CH
before
the third proton pulse. Heteronuclear product operator
calculations predict that the outcome should be the
same. Our results show that the response of
13
C
3
-glutamate
significantly differs depending on the
13
C
inversion pulse location. The signal is higher when the
pulse is placed at the beginning of the sequence. The
difference in response is due to strong homonuclear
coupling between the glutamate protons.
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