Abstract #3749
31 P-MRS reveals biliary phosphatidylcholine in the liver
Alessandra Bierwagen 1 , Peter Nowotny 1 , Jesper Lundbom 1 , Jrgen Bunke 2 , Julia Szendroedi 1 , and Michael Roden 1,3
1
Institute for Clinical Diabetology, German
Diabetes Center, Duesseldorf, Germany,
2
Philips
Healthcare, Hamburg, Germany,
3
Department
of Endocrinology and Diabetology, Heinrich Heine
University, Dsseldorf, Germany
The resonance at 2.06 ppm in the
31
P
human liver spectrum has been previously suggested to
arise from biliary phosphatidylcholine rather than from
phosphoenolpyruvate. Phantom measurements in the present
study support this thesis. In a retrospective analysis
the dependency of this peak from the distance to the
gallbladder was evaluated. Significant differences were
found between voxels i) with gall bladder infiltration,
ii) without gall bladder infiltration and iii) of
cholecystectomy subjects. Furthermore the
Phosphatidylcholine concentration correlates with bile
duct diameter (p = 0.03) and cholesterol blood levels (p
= 0.01). Therefore we suggest that biliary
phosphatidylcholine is detected in the liver.
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