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Abstract #3749

31 P-MRS reveals biliary phosphatidylcholine in the liver

Alessandra Bierwagen 1 , Peter Nowotny 1 , Jesper Lundbom 1 , Jrgen Bunke 2 , Julia Szendroedi 1 , and Michael Roden 1,3

1 Institute for Clinical Diabetology, German Diabetes Center, Duesseldorf, Germany, 2 Philips Healthcare, Hamburg, Germany, 3 Department of Endocrinology and Diabetology, Heinrich Heine University, Dsseldorf, Germany

The resonance at 2.06 ppm in the 31 P human liver spectrum has been previously suggested to arise from biliary phosphatidylcholine rather than from phosphoenolpyruvate. Phantom measurements in the present study support this thesis. In a retrospective analysis the dependency of this peak from the distance to the gallbladder was evaluated. Significant differences were found between voxels i) with gall bladder infiltration, ii) without gall bladder infiltration and iii) of cholecystectomy subjects. Furthermore the Phosphatidylcholine concentration correlates with bile duct diameter (p = 0.03) and cholesterol blood levels (p = 0.01). Therefore we suggest that biliary phosphatidylcholine is detected in the liver.

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