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Abstract #3669

Evaluation of 3D Deformable Registration to Improve Subtracted Dynamic Contrast Enhanced Liver Images for Characterization of Treated Hepatocellular Carcinoma

Dinesh K. Sundarakumar 1 , Gregory J. Wilson 1 , Sherif Osman 1 , and Jeffrey H. Maki 1

1 Radiology, University of Washington, Seattle, WA, United States

Subtraction of the pre-contrast phase in dynamic contrast enhanced (DCE) liver images is often necessary for accurate enhancement characterization of T1 hyperintense lesions such as treated hepatocellular carcinoma (HCC). However, variable displacement of the liver in successive breath-holds can lead to subtraction artifacts, making interpretation difficult. Furthermore, the liver is an elastic organ, and its displacement is not simply a rigid transformation. To address these issues, we evaluated an automatic 3D deformable registration algorithm for use in subtracted liver DCE. The method significantly reduced displacement (measured by anatomical landmarks) and improved the quality of subtracted images.

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