Abstract #3669
Evaluation of 3D Deformable Registration to Improve Subtracted Dynamic Contrast Enhanced Liver Images for Characterization of Treated Hepatocellular Carcinoma
Dinesh K. Sundarakumar 1 , Gregory J. Wilson 1 , Sherif Osman 1 , and Jeffrey H. Maki 1
1
Radiology, University of Washington,
Seattle, WA, United States
Subtraction of the pre-contrast phase in dynamic
contrast enhanced (DCE) liver images is often necessary
for accurate enhancement characterization of T1
hyperintense lesions such as treated hepatocellular
carcinoma (HCC). However, variable displacement of the
liver in successive breath-holds can lead to subtraction
artifacts, making interpretation difficult. Furthermore,
the liver is an elastic organ, and its displacement is
not simply a rigid transformation. To address these
issues, we evaluated an automatic 3D deformable
registration algorithm for use in subtracted liver DCE.
The method significantly reduced displacement (measured
by anatomical landmarks) and improved the quality of
subtracted images.
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