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Abstract #3670

Respiratory phase-resolved 3D MRI with isotropic high spatial resolution: Determination of the average breathing motion pattern for abdominal radiotherapy planning

Zhaoyang Fan 1 , Jianing Pang 1,2 , Wensha Yang 1 , Yong Yue 1 , Richard Tuli 1 , Guoxi Xie 1,3 , Xiaoming Bi 4 , Benedick Fraass 1 , and Debiao Li 1

1 Cedars-Sinai Medical Center, Los Angeles, CA, United States, 2 Northwestern University, Chicago, IL, United States, 3 Shenzhen Institutes of Advanced Technology, Shenzhen, Guangdong, United States, 4 MR R&D Siemens Healthcare, Los Angeles, CA, United States

Four-dimensional CT is currently a standard in radiotherapy planning to assess breathing motion and determine treatment margins for organ tumors. However, this modality has poor soft-tissue (or tumor) contrast and involves high radiation dose. These limitations can be overcome by using 4D MRI. The present work developed a retrospective 4D MRI technique (respiratory phase-resolved 3D MRI) that features: a) isotropic high spatial resolution (1.56 mm), b) a fixed scan time (8 minutes or less), c) an estimate of average respiratory phase resolved motion pattern with, and d) minimal intra-phase motion artifact.

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