Abstract #3605
Water fat separated MRI during cooling-reheating for the estimation of brown fat amount and activity
Elin Lundstrm 1 , Lars Johansson 1,2 , Peter Bergsten 3 , Hkan Ahlstrm 1 , and Joel Kullberg 1
1
Department of Radiology, Uppsala University,
Uppsala, Sweden,
2
AstraZeneca,
R&D Mlndal, Sweden,
3
Department
of Medical Cell Biology, Uppsala University, Uppsala,
Sweden
The purpose of this work was two-fold: 1) To evaluate
the effect of 3h cooling on human
cervical-supraclavicular adipose tissue fat fraction
(FF) and R2* 2) To evaluate the potential of a
cooling-reheating water-fat MRI protocol for assessing
brown adipose tissue (BAT) amount and activity. Imaging
was performed in nine volunteers (22-37 years, 5 males).
A general decrease in FF following 3h cold exposure was
observed, which confirms results from previous
PET/CT-studies. By adding a reheating timepoint to the
cold exposure protocol, the BAT activity in terms of
intracellular lipid consumption could potentially be
separated from perfusion effects.
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