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Abstract #3604

Resting acetylcarnitine concentration in skeletal muscle, as measured with long TE 1H-MRS, is associated with insulin sensitivity

Lucas Lindeboom 1 , Christine Nabuurs 1 , Joris Hoeks 2 , Maarten Vosselman 2 , Bram Brouwers 2 , Tineke van de Weijer 1 , Silvie Timmers 2 , Esther Phielix 2 , Eline Kooi 1 , Matthijs Hesselink 3 , Joachim Wildberger 1 , Patrick Schrauwen 2 , and Vera Schrauwen-Hinderling 1

1 Dept. of Radiology, MUMC+, Maastricht, Netherlands, 2 Dept. of Human Biology, MUMC+, Maastricht, Netherlands, 3 Dept. of Human Movement Sciences, MUMC+, Maastricht, Netherlands

The use of long TE in 1H-MRS enhances the visibility of the acetylcarnitine peak at 2.13 ppm. In this study we measured acetylcarnitine concentration in four groups, chosen to cover the whole range of metabolic health, from type 2 diabetic patients to endurance trained athletes. We found lower acetylcarnitine concentrations in subjects with lower insulin sensitivity. These results may indicate that T2DM subjects have a lower ability to form acetylcarnitine, possibly underlying a decreased insulin sensitivity and metabolic flexibility.

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