Abstract #3606
Effect of caloric and non-caloric sweeteners on liver lipid metabolism in rats
Sharon Janssens 1 , Klaas Nicolay 1 , and Jeanine J. Prompers 1
1
Eindhoven University of Technology,
Eindhoven, Netherlands
Excessive use of caloric sweeteners such as glucose and
fructose causes hepatic steatosis and obesity. To
sweeten food and drinks without the excessive calories,
non-caloric sweeteners can be used. In this study lipid
metabolism in the liver of rats receiving different
caloric and non-caloric sweeteners is examined using
1
H-[
13
C]
MRS combined with the administration of
13
C-labeled
lipids. The non-caloric sweetener aspartame did not have
any effect on liver lipid content or metabolism. In
contrast, carbohydrate consumption resulted in increased
liver lipid content, which was not accompanied by an
increased uptake of dietary lipids and is thus likely
caused by increased lipogenesis.
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