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Abstract #3550

A quantitative technique for assessing the temporal dynamics of regional specific ventilation in response to methacholine challenge in asthma using oxygen enhanced proton MRI

Rui Carlos S 1 , Amran K Asadi 1 , Rebecca J Theilmann 2 , and G. Kim Prisk 1,2

1 Medicine, University of California, San Diego, La Jolla, CA, United States, 2 Radiology, University of California, San Diego, La Jolla, CA, United States

Asthma is a dynamic disease that possesses strong, poorly understood temporal components. We describe an improved analysis of Specific Ventilation Imaging - a quantitative oxygen-enhanced MR-technique - that may be useful in elucidating time-varying ventilation heterogeneity after acute asthma events. Specific ventilation is quantified by comparing the modeled response of ideal lung units with individual voxel signal intensity time-series, following changes from breathing air to oxygen. Temporal changes are captured using an overlapping running window (120 breaths, 600s, shifted by 200s). Regional ventilation is seen to recover towards baseline over time following bronchoconstriction of a mild asthmatic subject with methacholine.

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