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Abstract #3551

Pulmonary Ultra-short Echo-time (UTE) Two-dimensional Radial Acquisition with Compressed Sensing: Preliminary Quantitative Results with Comparison to Thoracic CT

Weijing Ma 1 , Khadija Sheikh 1,2 , Jonathon Leipsic 3 , Harvey O Coxson 3 , David G McCormack 4 , Roya Etemad-Rezai 5 , and Grace Parraga 1,2

1 Imaging Research Laboratories, Robarts Research Institute, London, Ontario, Canada, 2 Department of Medical Biophysics, The University of Western Ontario, Ontario, Canada, 3 Department of Radiology, University of British Columbia, Vancouver, British Columbia, Canada, 4 Department of Medicine, The University of Western Ontario, London, Ontario, Canada, 5 Department of Medical Imaging, The University of Western Ontario, London, Ontario, Canada

We developed thoracic 32-channel ultra-short echo time radial 1H MRI with compressed sensing to achieve quantitative 1H signal intensity maps on a clinical 3T scanner for quantitative measurements of the lung parenchyma. Such measurements were directly compared in healthy volunteers at different lung volumes and in patients with COPD and bronchiectasis with 3He MRI apparent diffusion coefficients, CT measurements of tissue density and pulmonary function test measurements. Compressed sensing UTE MRI was successfully implemented at 3T and showed significantly improved SI measurements acquired at expiration breath-hold that is safe and practical for patients with chronic respiratory disease.

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