Abstract #3506
Hippocampus is sensitive to hypoxia ischemia in neonatal rat: an in vivo magnetic resonance spectroscopy study
Su Xu 1,2 , Jaylyn Waddell 3 , Da Shi 1,2 , Wenjun Zhu 1,2 , Andrew Marshall 1,2 , Rao Gullapalli 1,2 , and Mary C McKenna 3
1
Department of Diagnostic Radiology and
Nuclear Medicine, University of Maryland School of
Medicine, Baltimore, MD, United States,
2
Core
for Translational Research in Imaging @ Maryland,
Baltimore, MD, United States,
3
Department
of Pediatrics and Program in Neuroscience, University of
Maryland School of Medicine, Baltimore, MD, United
States
A key requirement for developing efficient therapies to
treat the perinatal hypoxic ischemia (HI) is to identify
alterations that occur following a brain insult at early
stages of brain development. The present study evaluated
the regional brain metabolic alterations from moderate
neonatal HI rats that were followed up to 28 days after
initial injury using
in
vivo
high
resolution
1
H
MRS. Severe oxidative, osmotic stress, impaired
oxidative phosphorylation, and consequent reliance on
anaerobic glycolysis were found in the ipsilateral
hippocampus. The results indicate that the developing
hippocampus is sensitive to HI which may have a profound
impact on neurodevelopment.
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