Abstract #3507
The expression of normal motor-related functional pattern using fMRI and PET in sporadic dystonia
Wataru Sako 1 , An Vo 1 , Aziz M Uluğ 1 , and David Eidelberg 1
1
Center for Neurosciences, Feinstein
Institute For Medical Research, Manhasset, NY, United
States
Normal motor-related pattern (NMRP) was originally
identified in H215O PET study by multivariate analysis
based on principal component analysis, and found to be
more strongly expressed in patients with DYT1 dystonia
than normal controls. Studying a group of subjects with
both fMRI and PET, we derived NMRP from each imaging
modality. We then applied the pattern in a group of
sporadic dystonia patients. We found that sporadic
dystonia patients did not have elevated NMRP expression,
hence the increase previously seen in DYT1 dystonia
patients may have genetic causes.
This abstract and the presentation materials are available to members only;
a login is required.
Join Here
