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Abstract #3505

Blood-Brain Barrier Stabilization Effects of Agmatine Assessed by Dynamic Contrast-Enhanced MRI in a Rat Model of Transient Cerebral Ischemia

Sung Soo Ahn 1 , Se Hoon Kim 2 , Jong Eun Lee 3 , Kook Jin Ahn 4 , Dong Joon Kim 1 , Hyun Seok Choi 4 , Seung-Koo Lee 1 , and Yoon Seong Choi 1

1 Radiology, Yonsei University College of Medicine, Seoul, Seoul, Korea, 2 Pathology, Yonsei University College of Medicine, Seoul, Korea, 3 Anatomy, Yonsei University College of Medicine, Seoul, Korea, 4 Radiology, The Catholic University College of Medicine, Seoul, Korea

This study is about quantitative evaluation of blood-brain barrier stabilization effect of agmatine in rat models of transient cerebral ischemia using dynamic contrast-enhanced MRI at early stages to reduce the complications associated with thrombolytic therapy in ischemic stroke, and demonstrated the feasibility of DCE-MRI for the investigation of new therapies.

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