Abstract #3504
Quantitative relaxometry reveals the early involvement of rostral white matter tracts in a murine model of cerebral malaria
Teodora-Adriana Perles-Barbacaru 1 , Emilie Pecchi 1 , Monique Bernard 1 , Patrick J Cozzone 1 , and Angele Viola 1
1
CRMBM UMR CNRS 7339, Aix Marseille
University, Marseille, France
Although some anatomical abnormalities can be observed
on conventional MRI in cerebral malaria, they lack
pathological specificity and are not easily
quantifiable. To further characterize a murine model of
cerebral malaria we acquired quantitative T1 and T2 maps
at 11.75T. The maps display significant increase in T2
and T2* in white matter tracts, notably in the olfactory
limb of the anterior commissure preceding the occurrence
of more caudal lesions. Although challenging at high
magnetic field, quantitative mapping of relaxation
parameters may provide sensitive markers of disease
progression and help elucidate the underlying
pathophysiological mechanism.
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