Abstract #3491
Effects of Chronic Ocular Hypertension on Microstructural Integrity of the Visual System using Diffusion Tensor MRI
Leon C. Ho 1,2 , Hongmin Yun 3 , Seong-Gi Kim 1,4 , Ed X. Wu 2 , Yiqin Du 3 , and Kevin C. Chan 1,3
1
Neuroimaging Laboratory, Department of
Radiology, University of Pittsburgh, Pittsburgh,
Pennsylvania, United States,
2
Department
of Electrical and Electronic Engineering, The University
of Hong Kong, Pokfulam, Hong Kong, China,
3
Department
of Ophthalmology, University of Pittsburgh, Pittsburgh,
Pennsylvania, United States,
4
Center
for Neuroscience Imaging Research, Institute for Basic
Science (IBS), Dept. of Biological Sci, SKKU, Suwon,
Korea
Glaucoma is a slow, irreversible neurodegenerative
disease of the visual system, whose disease mechanisms
are still poorly understood. Using a mouse model of
laser-induced chronic ocular hypertension mimicking
chronic glaucoma in humans, this study applied diffusion
tensor imaging (DTI) to study the microstructural
integrity spatially along the visual pathways. The
results appeared to indicate the involvement of
Wallerian-like anterograde degeneration as a candidate
of the disease mechanisms of chronic ocular hypertension
in the brain, with different progressive rates of
neurodegenerative events occurring along the visual
pathways.
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