Abstract #3492
Functional Connectivity Hubs in the Conscious Marmoset Monkey
Dardo Tomasi 1 , Annabelle Belcher 2 , Cecil Chern-Chyi Yen 3 , Lucia Notardonato 2 , Thomas J. Ross 2 , Yihong Yang 2 , Elliot A. Stein 2 , Nora D. Volkow 2 , and Afonso C Silva 3
1
NIAAA-IRP, National Institutes of Health,
Bethesda, MD, United States,
2
NIDA-IRP,
National Institutes of Health, MD, United States,
3
NINDS-IRP,
National Institutes of Health, MD, United States
Resting-State Functional Connectivity (RSFC) is an
emerging method to study the organization of large-scale
brain networks; yet appropriate animal models (nonhuman
primates) are hampered by the requirement for
anesthesia. Here we present fMRI data from 6 male
marmosets trained for awake fMRI procedures. Utilizing
an ultrafast, data-driven method to identify local
functional connectivity hubs in humans, we found that
the marmoset brain possesses several connectivity hubs;
primarily in visual, parietal, and frontal cortical
areasregions that overlap well with the connectivity
hubs found in the human brain. We submit the awake
marmoset as an important tool for exploring RSFC
questions.
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