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Abstract #3492

Functional Connectivity Hubs in the Conscious Marmoset Monkey

Dardo Tomasi 1 , Annabelle Belcher 2 , Cecil Chern-Chyi Yen 3 , Lucia Notardonato 2 , Thomas J. Ross 2 , Yihong Yang 2 , Elliot A. Stein 2 , Nora D. Volkow 2 , and Afonso C Silva 3

1 NIAAA-IRP, National Institutes of Health, Bethesda, MD, United States, 2 NIDA-IRP, National Institutes of Health, MD, United States, 3 NINDS-IRP, National Institutes of Health, MD, United States

Resting-State Functional Connectivity (RSFC) is an emerging method to study the organization of large-scale brain networks; yet appropriate animal models (nonhuman primates) are hampered by the requirement for anesthesia. Here we present fMRI data from 6 male marmosets trained for awake fMRI procedures. Utilizing an ultrafast, data-driven method to identify local functional connectivity hubs in humans, we found that the marmoset brain possesses several connectivity hubs; primarily in visual, parietal, and frontal cortical areasregions that overlap well with the connectivity hubs found in the human brain. We submit the awake marmoset as an important tool for exploring RSFC questions.

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