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Abstract #3490

Imatinib reduces blood-brain barrier permeability in a transient occlusion-reperfusion rodent model: A DCE-MRI study

Zamir Merali 1 , Jackie Leung 1 , and Andrea Kassner 1,2

1 Physiology and Experimental Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada, 2 Medical Imaging, University of Toronto, Toronto, Ontario, Canada

The platelet-derived growth factor inhibitor, Imatinib, has been shown to reduce blood-brain barrier (BBB) permeability in a variety of neurologic conditions. However, the clinical utility of this type of treatment for ischemic stroke is still uncertain. We proposed to use structural and DCE-MRI to quantify the BBB stabilizing effect of Imatinib in a rodent stroke model. Male Sprague-Dawley rats (n=25) underwent MCA occlusion-perfusion surgery and was imaged at 5 and 24 hours. Treatment group rats received Imatinib while controls received an equivalent volume of saline. At 24-hours, the Imatinib group had reduced infarct size and permeability compared to controls.

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