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Abstract #3486

Biomarkers to estimate the time of onset of cerebral ischemia

Carole Berthet 1 , Lijing Xin 2 , Corine Benakis 1 , Rolf Gruetter 2,3 , Lorenz Hirt 1 , and Hongxia Lei 4,5

1 Department of Clinical Neurosciences, Centre Hospitalier Universitaire Vaudois, Lausanne, Vaud, Switzerland, 2 LIFMET, cole Polytechnique Fdrale de Lausanne, Vaud, Switzerland, 3 Univesity of Lausanne, Vaud, Switzerland, 4 CIBM-AIT, cole Polytechnique Fdrale de Lausanne, Lausanne, Vaud, Switzerland, 5 University of Geneva, Geneva, Geneva, Switzerland

Thrombolysis, the only currently available treatment for ischemic stroke can be administered only in a narrow time window of 4.5 hours. A significant number of patients have an unknown time of onset as the stroke occurred during their sleep, which disqualifies them for thrombolysis. The objective of this study was to determine whether 1H MRS of the ischemic striatum could provide useful information on the estimation of the onset time of cerebral ischemia.

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