Abstract #3485
MRI Detection and Histological Correlates of the Dependence of Brain Damage on Recovery Time Between Recurrent Mild Strokes.
Qinbo Deng 1 , Min Qiao 2 , Tadeusz Foniok 3 , Dave Rushforth 3 , and Ursula I Tuor 2,4
1
University of Calgary, Calgary, Alberta,
Canada,
2
Physiology
and Pharmacology, University of Calgary, Alberta,
Canada,
3
Experimental
Imaging Centre, University of Calgary, Alberta, Canada,
4
Cl
Neurosciences and Radiology, University of Calgary,
Alberta, Canada
Recovery from an initial mild ischemic insult could
influence the susceptibility of the brain to a second
insult. We assessed brain damage using magnetic
resonance imaging and histology comparing brain damage
produced by a combination of two mild transient ischemic
insults with intervals of either 1 day, 2 day, 3 day or
1 week. A recurrent mild PT enhanced the tissue damage
and this enhancement was greater with a short recovery
(1-3d) versus a longer recovery (1w) between insults.
This indicates that brain is most susceptible to a
second mild ischemic insult for several days after a
first insult.
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