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Abstract #3484

Longitudinal functional connectivity changes in Middle Cerebral Artery Occlusion: correlation with diffusion, T2 and behavioral outcomes

Lora Talley Watts 1 , Shiliang Huang 1 , Qiang Shen 1 , Justin Alexander Long 1 , Wei Li 1 , and Timothy Duong 1

1 Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States

This study examined longitudinally the rsfMRI changes following a 45-min MCAO in rats up to 28 days. Quantitative correlations were made with T2, DTI, fractional anisotropy (FA), and functional outcomes (forelimb placement asymmetry and foot fault scores). rsfMRI z-scores reduced after MCAO but improved with time. The trend of improvement parallels those of behavioral scores. rsfMRI did not significantly correlate with ADC, FA and T2 changes, suggesting they provide complementary information. This study demonstrated that rsfMRI offers novel insight into functional connectivity following MCAO.

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