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Abstract #3483

Investigation of Angiogenesis following CART peptide Treatment in Transient Ischemic Rat Stroke Model Using Susceptibility-Weighted Imaging

Hua-Shan Liu 1 , Hui Shen 1 , Yu Luo 1 , Hanbing Lu 1 , Yun Wang 1 , and Yihong Yang 1

1 National Institute on Drug Abuse, Baltimore, MD, United States

We applied the SWI technique in a rat stroke model to quantitatively investigate cerebral angiogenesis after stroke with Cocaine- and amphetamine-regulated transcript (CART) treatment. Our data demonstrated that SWI identifies cerebral angiogenesis in areas surrounding the infarction, and CART treatment enhances angiogenesis than that of the saline treated rats.

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