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Abstract #3482

microstructural brain abnormalities in patients with major earthquake-induced posttraumatic stress disorder: a diffusion tensor imaging study

Lei Li 1 , Du Lei 1 , Xueling Suo 1 , Fenglai Xiao 2 , Min Wu 1 , Xiaoqi Huang 1 , and Qiyong Gong 1

1 Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hosipital of Sichuan University, Chengdu, Sichuan, China, 2 West China Hosipital of Sichuan University, Department of Neurology, Chengdu, Sichuan, China

We included 88 PTSD patients and 91 matched survivors without PTSD suffering from a severe earthquake for DTI assessment. Besides voxel-based analysis, we also conducted an exploratory research by searching for the correlations between all possible pairs of affected white matter regions to detect the altered pattern of interregional correlations of microstructural abnormalities in PTSD. Our results demonstrated the white matter abnormality in frontal-temporal system and putative correlations between these two areas. Moreover, the absence of positive correlation between prefrontal regions and precuneus in our results may suggest a potential disruption of the central executive network in PTSD patients.

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