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Abstract #3487

Measurement of distinctive features of Cortical Spreading Depolarizations with different MRI contrasts

Suryanarayana Umesh Rudrapatna 1 , Arend Hamming 1,2 , Marieke J H Wermer 2 , Annette van der Toorn 1 , and Rick M Dijkhuizen 1

1 University Medical Center Utrecht, Utrecht, Netherlands, 2 Leiden University Medical Center, Leiden, Netherlands

Gradient-echo and diffusion-weighted scans have been used to assess spreading depolarizations (SD) in the brain, a pathophysiological phenomenon implicated in various neurological disorders. We evaluated two alternative MRI techniques, b-SSFP and diffusion-weighted multi-spin-echo (DT2), in their potential to improve detection and characterization of SD in rat brain. b-SSFP, with underpinning spin-echo contrast, demonstrated higher spatiotemporal specificity than gradient-echo scanning. DT2 scanning, with the ability to concurrently measure hemodynamic (T 2 ) and cellular changes (ADC), was shown to offer a multi-parametric means to gain insights into co-occurring vascular and cellular changes during SD.

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