Meeting Banner
Abstract #3479

Hippocampal atrophy in major depression rather a function of childhood maltreatment?

Harald Kugel 1 , Nils Opel 2 , Ronny Redlich 2 , Peter Zwanzger 2 , Dominik Grotegerd 2 , Volker Arolt 2 , Walter Heindel 1 , Carsten Konrad 3 , and Udo Dannlowski 2,3

1 Department of Clinical Radiology, University of Muenster, Muenster, NRW, Germany, 2 Department of Psychiatry, University of Muenster, Muenster, NRW, Germany, 3 Department of Psychiatry, University of Marburg, Marburg, He, Germany

This fMRI study investigates the frequently reported smaller volume of the hippocampus in patients diagnosed with major depressive disorder (MDD) compared to healthy controls. Reduced hippocampus volumes have also been reported for subjects affected by childhood maltreatment, independently of a diagnosis of MDD. The analysis of our morphometric measurements revealed that while childhood maltreatment was associated with hippocampal volume loss in both, patients and healthy controls, there was no longer a difference between the groups if maltreatment was regressed out. This may provide an alternative explanation for limbic structural alterations in depressed patients.

This abstract and the presentation materials are available to members only; a login is required.

Join Here