Abstract #3480
Multi-Echo fMRI Atlas of Seed-Based Functional Connectivity with Power Analysis
Prantik Kundu 1 , Mike Irvine 2 , Petra Vertes 2 , Peter Bandettini 1 , Ed Bullmore 2 , and Valerie Voon 2
1
NIMH, Bethesda, MD, United States,
2
Department
of Psychiatry, Cambridge University, Cambridge, United
Kingdom
We present a novel atlas of group-level seed-based
functional connectivity based on multi-echo (ME) fMRI
datasets from a large cohort of normal controls (N=139),
with connectivity estimation by ME independent
coefficients regression (ICR). We demonstrate compelling
cortical and subcortical seed-based connectivity maps,
alongside power analyses showing optimal sample sizes
for assessing specific seed-target connectivity, such as
between orbitofrontal cortex and hippocampus. These
results add to recent findings of 4-fold increases in
tSNR after ME-ICA BOLD denoising, and are relevant to
groups currently acquiring ME data or considering doing
so.
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