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Abstract #3480

Multi-Echo fMRI Atlas of Seed-Based Functional Connectivity with Power Analysis

Prantik Kundu 1 , Mike Irvine 2 , Petra Vertes 2 , Peter Bandettini 1 , Ed Bullmore 2 , and Valerie Voon 2

1 NIMH, Bethesda, MD, United States, 2 Department of Psychiatry, Cambridge University, Cambridge, United Kingdom

We present a novel atlas of group-level seed-based functional connectivity based on multi-echo (ME) fMRI datasets from a large cohort of normal controls (N=139), with connectivity estimation by ME independent coefficients regression (ICR). We demonstrate compelling cortical and subcortical seed-based connectivity maps, alongside power analyses showing optimal sample sizes for assessing specific seed-target connectivity, such as between orbitofrontal cortex and hippocampus. These results add to recent findings of 4-fold increases in tSNR after ME-ICA BOLD denoising, and are relevant to groups currently acquiring ME data or considering doing so.

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